the impact of radiation therapy, given after mitoxantrone, vincristine, vinblastine, and prednisone (novp) chemotherapy, on sperm production is the focus of this study. Patients serial semen analyses were performed on 34 patients with hd stages i-iii before novp chemotherapy, after chemotherapy prior to radiation, and after radiation therapy. prednisone side effects in men comprise of osteoporosis, dizziness, indigestion, abdominal pain etc. The side effects of prednisone are same for men and women, as prednisone works the same way for both men and women. The only difference for men seems to be the impact on the movement and number of sperms. Occasionally, sperm production never returns and the man becomes infertile. If you are preparing to go on chemotherapy, talk to your doctor about freezing sperm before starting the chemotherapy. Other medications the following medications may cause male fertility problems some antibiotics, spironolactone, cimetidine, nifedipine. There are few studies on the effects of drugs on pregnant women and even fewer studies on the effects of drugs on sperm. I was able to find that prednisone can decrease the amount of sperm produced by the male taking prednisone and also the sperm may have less motility which means they dont swim well and so this could present a problem in getting pregnant. id personally be worried about trying to conceive while either of us are on prednisone. Heshe will know best about side effects involving sperm and pregnancy. Ive done a little bit of research, but havent heard anything about it. prednisone reference guide for safe and effective use from the american society of health-system pharmacists (ahfs di). Increased or decreased motility and number of sperm in some men. Interfere with endogenous glucocorticoid production, or cause other adverse effects in nursing infants. However, sperm production recovered very rapidly, within 3 to 4 months after the end of novp chemotherapy. This pattern was caused by killing differentiating spermatogenic cells, but there was little cytotoxicity or inhibition of stem cells from mitoxantrone or the other drugs. Prednisone affect sperm best answer yes, prednisone is a corticosteroid, which will cause a huge decrease in sperm production. Drugs that may affect fertility by preconception weekly does prednisone affect sperm count? - mcrh. Sperm production requires 2 hormones fsh (produced by the brain) and testosterone (produced by the testicle). Steroids cause receptors in the brain to generate a hormone called inhibin that prevents the production of lh and fsh. in fact, in cases where one has antibodies to ones own sperm, prednisone is used to improve sperm motility. If you have any concerns just use reply to expert until you are ready to rate a positive for your satisfaction.